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The use of the fixed-dose combination may represent advantage in terms of efficacy and safety, allowing a better control of the dose of both paracetamol and ibuprofen as monotherapy, thus minimizing the risk of incorrect dosage. However, the limited evidence available highlights the need for future.. Results. Pharmacokinetic parameters for ibuprofen and paracetamol were similar for the combination and monotherapy tablets (values falling within the 80% to 125% acceptable bioequivalence range) except for the rate of absorption of paracetamol from the combination (t max), which was significantly faster compared with monotherapy (median difference 10 minutes; p < 0.05).


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Ibuprofen plus paracetamol, administered as a single oral dose, compared with matched placebo or the same dose of ibuprofen alone for postoperative pain. The ibuprofen and paracetamol had to be administered as separate tablets taken together, or in a combined tablet. We included all dose combinations.. Taking ibuprofen with other painkillers. It's safe to take ibuprofen with paracetamol or codeine. But do not take ibuprofen with similar painkillers like aspirin or naproxen without talking to a pharmacist or doctor. Ibuprofen, aspirin and naproxen belong to the same group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).